[Pharmacologic efficacy of sodium alginate suspension on gastro-esophageal reflux in infants and children].
Identifieur interne : 002520 ( Main/Exploration ); précédent : 002519; suivant : 002521[Pharmacologic efficacy of sodium alginate suspension on gastro-esophageal reflux in infants and children].
Auteurs : B. Le Luyer [France] ; J F Mougenot ; L. Mashako ; P. Chapoy ; J P Olives ; A. Morali ; B. Chevallier ; J L Ginies ; C. Dupont ; M. DagorneSource :
- Archives francaises de pediatrie [ 0003-9764 ] ; 1990.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Alginates.
- chemical , pharmacology : Alginates.
- chemical , therapeutic use : Alginates.
- drug therapy : Gastroesophageal Reflux.
- Child, Preschool, Female, Humans, Hydrogen-Ion Concentration, Infant, Infant, Newborn, Male, Reference Values, Suspensions.
Abstract
Eighty-three children presenting with symptomatic gastro-esophageal reflux (GER) (48 males, 35 females, aged 15 days to 57 months (mean = 7 months) were assessed by pH monitoring. All showed acid pathological GER on the 3 hours post-prandial esophageal pH measurement (% of time at pH less than 4 greater than 4.2) and all had a second pH measurement within the following 3 hours after intake of a single (5 ml) dose of sodium alginate (AGS). AGS administration was followed by a highly significant reduction (p less than 0.00001) of all pH measurement variables: a) Percentage of time spent at pH less than 4 returned to normal with a mean 11.7% to 4.8%; that is a 52.5% improvement (median); b) Total number of reflux reduced on average from 8.9 to 5.0: that is a 35% improvement (median); c) Mean duration of reflux reduced on average for 4 to 2 min; that is a 60% improvement (median). In 76 patients hourly monitoring of % of time spent at pH less than 4 shows that hourly improvement persists.
PubMed: 2322080
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000440
- to stream PubMed, to step Curation: 000440
- to stream PubMed, to step Checkpoint: 000440
- to stream Ncbi, to step Merge: 000341
- to stream Ncbi, to step Curation: 000341
- to stream Ncbi, to step Checkpoint: 000341
- to stream Main, to step Merge: 002590
- to stream Main, to step Curation: 002520
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[Pharmacologic efficacy of sodium alginate suspension on gastro-esophageal reflux in infants and children].</title>
<author><name sortKey="Le Luyer, B" sort="Le Luyer, B" uniqKey="Le Luyer B" first="B" last="Le Luyer">B. Le Luyer</name>
<affiliation wicri:level="3"><nlm:affiliation>Services de: Gastro-Entérologie pédiatrique, Centre Hospitalier, Le Havre.</nlm:affiliation>
<country>France</country>
<placeName><settlement type="city">Le Havre</settlement>
<region type="région" nuts="2">Région Normandie</region>
<region type="old region" nuts="2">Haute-Normandie</region>
</placeName>
<wicri:orgArea>Services de: Gastro-Entérologie pédiatrique, Centre Hospitalier</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Mougenot, J F" sort="Mougenot, J F" uniqKey="Mougenot J" first="J F" last="Mougenot">J F Mougenot</name>
</author>
<author><name sortKey="Mashako, L" sort="Mashako, L" uniqKey="Mashako L" first="L" last="Mashako">L. Mashako</name>
</author>
<author><name sortKey="Chapoy, P" sort="Chapoy, P" uniqKey="Chapoy P" first="P" last="Chapoy">P. Chapoy</name>
</author>
<author><name sortKey="Olives, J P" sort="Olives, J P" uniqKey="Olives J" first="J P" last="Olives">J P Olives</name>
</author>
<author><name sortKey="Morali, A" sort="Morali, A" uniqKey="Morali A" first="A" last="Morali">A. Morali</name>
</author>
<author><name sortKey="Chevallier, B" sort="Chevallier, B" uniqKey="Chevallier B" first="B" last="Chevallier">B. Chevallier</name>
</author>
<author><name sortKey="Ginies, J L" sort="Ginies, J L" uniqKey="Ginies J" first="J L" last="Ginies">J L Ginies</name>
</author>
<author><name sortKey="Dupont, C" sort="Dupont, C" uniqKey="Dupont C" first="C" last="Dupont">C. Dupont</name>
</author>
<author><name sortKey="Dagorne, M" sort="Dagorne, M" uniqKey="Dagorne M" first="M" last="Dagorne">M. Dagorne</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="1990">1990</date>
<idno type="RBID">pubmed:2322080</idno>
<idno type="pmid">2322080</idno>
<idno type="wicri:Area/PubMed/Corpus">000440</idno>
<idno type="wicri:Area/PubMed/Curation">000440</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000440</idno>
<idno type="wicri:Area/Ncbi/Merge">000341</idno>
<idno type="wicri:Area/Ncbi/Curation">000341</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000341</idno>
<idno type="wicri:doubleKey">0003-9764:1990:Le Luyer B:pharmacologic:efficacy:of</idno>
<idno type="wicri:Area/Main/Merge">002590</idno>
<idno type="wicri:Area/Main/Curation">002520</idno>
<idno type="wicri:Area/Main/Exploration">002520</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">[Pharmacologic efficacy of sodium alginate suspension on gastro-esophageal reflux in infants and children].</title>
<author><name sortKey="Le Luyer, B" sort="Le Luyer, B" uniqKey="Le Luyer B" first="B" last="Le Luyer">B. Le Luyer</name>
<affiliation wicri:level="3"><nlm:affiliation>Services de: Gastro-Entérologie pédiatrique, Centre Hospitalier, Le Havre.</nlm:affiliation>
<country>France</country>
<placeName><settlement type="city">Le Havre</settlement>
<region type="région" nuts="2">Région Normandie</region>
<region type="old region" nuts="2">Haute-Normandie</region>
</placeName>
<wicri:orgArea>Services de: Gastro-Entérologie pédiatrique, Centre Hospitalier</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Mougenot, J F" sort="Mougenot, J F" uniqKey="Mougenot J" first="J F" last="Mougenot">J F Mougenot</name>
</author>
<author><name sortKey="Mashako, L" sort="Mashako, L" uniqKey="Mashako L" first="L" last="Mashako">L. Mashako</name>
</author>
<author><name sortKey="Chapoy, P" sort="Chapoy, P" uniqKey="Chapoy P" first="P" last="Chapoy">P. Chapoy</name>
</author>
<author><name sortKey="Olives, J P" sort="Olives, J P" uniqKey="Olives J" first="J P" last="Olives">J P Olives</name>
</author>
<author><name sortKey="Morali, A" sort="Morali, A" uniqKey="Morali A" first="A" last="Morali">A. Morali</name>
</author>
<author><name sortKey="Chevallier, B" sort="Chevallier, B" uniqKey="Chevallier B" first="B" last="Chevallier">B. Chevallier</name>
</author>
<author><name sortKey="Ginies, J L" sort="Ginies, J L" uniqKey="Ginies J" first="J L" last="Ginies">J L Ginies</name>
</author>
<author><name sortKey="Dupont, C" sort="Dupont, C" uniqKey="Dupont C" first="C" last="Dupont">C. Dupont</name>
</author>
<author><name sortKey="Dagorne, M" sort="Dagorne, M" uniqKey="Dagorne M" first="M" last="Dagorne">M. Dagorne</name>
</author>
</analytic>
<series><title level="j">Archives francaises de pediatrie</title>
<idno type="ISSN">0003-9764</idno>
<imprint><date when="1990" type="published">1990</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alginates (administration & dosage)</term>
<term>Alginates (pharmacology)</term>
<term>Alginates (therapeutic use)</term>
<term>Child, Preschool</term>
<term>Female</term>
<term>Gastroesophageal Reflux (drug therapy)</term>
<term>Humans</term>
<term>Hydrogen-Ion Concentration</term>
<term>Infant</term>
<term>Infant, Newborn</term>
<term>Male</term>
<term>Reference Values</term>
<term>Suspensions</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Alginates</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Alginates</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Alginates</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Gastroesophageal Reflux</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Child, Preschool</term>
<term>Female</term>
<term>Humans</term>
<term>Hydrogen-Ion Concentration</term>
<term>Infant</term>
<term>Infant, Newborn</term>
<term>Male</term>
<term>Reference Values</term>
<term>Suspensions</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Eighty-three children presenting with symptomatic gastro-esophageal reflux (GER) (48 males, 35 females, aged 15 days to 57 months (mean = 7 months) were assessed by pH monitoring. All showed acid pathological GER on the 3 hours post-prandial esophageal pH measurement (% of time at pH less than 4 greater than 4.2) and all had a second pH measurement within the following 3 hours after intake of a single (5 ml) dose of sodium alginate (AGS). AGS administration was followed by a highly significant reduction (p less than 0.00001) of all pH measurement variables: a) Percentage of time spent at pH less than 4 returned to normal with a mean 11.7% to 4.8%; that is a 52.5% improvement (median); b) Total number of reflux reduced on average from 8.9 to 5.0: that is a 35% improvement (median); c) Mean duration of reflux reduced on average for 4 to 2 min; that is a 60% improvement (median). In 76 patients hourly monitoring of % of time spent at pH less than 4 shows that hourly improvement persists.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Haute-Normandie</li>
<li>Région Normandie</li>
</region>
<settlement><li>Le Havre</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Chapoy, P" sort="Chapoy, P" uniqKey="Chapoy P" first="P" last="Chapoy">P. Chapoy</name>
<name sortKey="Chevallier, B" sort="Chevallier, B" uniqKey="Chevallier B" first="B" last="Chevallier">B. Chevallier</name>
<name sortKey="Dagorne, M" sort="Dagorne, M" uniqKey="Dagorne M" first="M" last="Dagorne">M. Dagorne</name>
<name sortKey="Dupont, C" sort="Dupont, C" uniqKey="Dupont C" first="C" last="Dupont">C. Dupont</name>
<name sortKey="Ginies, J L" sort="Ginies, J L" uniqKey="Ginies J" first="J L" last="Ginies">J L Ginies</name>
<name sortKey="Mashako, L" sort="Mashako, L" uniqKey="Mashako L" first="L" last="Mashako">L. Mashako</name>
<name sortKey="Morali, A" sort="Morali, A" uniqKey="Morali A" first="A" last="Morali">A. Morali</name>
<name sortKey="Mougenot, J F" sort="Mougenot, J F" uniqKey="Mougenot J" first="J F" last="Mougenot">J F Mougenot</name>
<name sortKey="Olives, J P" sort="Olives, J P" uniqKey="Olives J" first="J P" last="Olives">J P Olives</name>
</noCountry>
<country name="France"><region name="Région Normandie"><name sortKey="Le Luyer, B" sort="Le Luyer, B" uniqKey="Le Luyer B" first="B" last="Le Luyer">B. Le Luyer</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/France/explor/LeHavreV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002520 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002520 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/France |area= LeHavreV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:2322080 |texte= [Pharmacologic efficacy of sodium alginate suspension on gastro-esophageal reflux in infants and children]. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:2322080" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a LeHavreV1
This area was generated with Dilib version V0.6.25. |